Nielsen Holdings, FedEx, LHC Group, and other companies are experiencing significant price changes before the market opens.

Take a look at some of the biggest movers in the premarket:

The private-equity consortium agreed to acquire the TV ratings company for $28 per share, resulting in a 20.9% increase in the company's stock price in the premarket. The deal is valued at $16 billion, including assumed debt.

FedEx CEO Fred Smith, who founded the company over 50 years ago, will step down from his role as CEO on June 1 and become executive chairman. He will be replaced as CEO by President and Chief Operating Officer Raj Subramaniam. FedEx shares rose 2% in the premarket.

The home health-care specialist, LHCG, will be acquired by UNH for $5.4 billion in cash or $170 per share, according to The Wall Street Journal. LHC will now be part of UnitedHealth's Optum health-care services unit. LHC shares increased by 7.5% in premarket trading.

Uber is on the brink of reaching a deal with a San Francisco taxi company to integrate taxis into its ride-hailing platform in that city, sources close to the matter have revealed to The New York Times. This news comes after Uber recently struck a similar agreement in New York City. As a result, the stock price increased by 1.9% during premarket trading.

The asset management firm's stock surged 3.7% in the premarket after reporting better-than-expected quarterly earnings and revenue. Despite a decline in profit from the previous year, Jefferies exceeded the consensus estimate of $89 cents a share with earnings of $1.23 per share. The company attributed the challenging trading environment to its decline in profit.

The stock of GameStop continues to be monitored as it experiences a 10-day winning streak, resulting in a 143% increase. Meanwhile, another "meme stock," AMC, had a 45% surge on Monday, its best day since June. Despite this, GameStop fell 3.5% in premarket trading, while AMC slid 4.5%.

The Illinois Jeep plant of the automaker is laying off an undisclosed number of workers to operate the plant in a more sustainable manner. The plant experienced layoffs last year due to the global semiconductor shortage. Stellantis shares increased by 4.5% in premarket trading.

The energy producer plans to sell $400 million in shares at $74 per share to repay debt used in its $2 billion acquisition of Questar Pipelines in December. This move was prompted by the rejection of an offer from investor Carl Icahn to buy Southwest at $82.50 per share on Monday. As a result, Southwest's stock price fell 3.4% in the premarket.

The restaurant chain's stock price dropped 5.9% in the premarket after missing both top and bottom-line estimates in its latest quarter. Dave & Buster's fell 8 cents short of expectations, with quarterly earnings of 52 cents per share. Despite ongoing Covid-19 challenges, the company said its results were strong.

The image-sharing site operator's shares dropped 2.7% in premarket trading after Morgan Stanley downgraded it to "equal-weight" from "overweight." Morgan Stanley cited challenging user trends, such as a higher proportion of time spent on activities with lower monetization potential, as the reason for the downgrade.